Htm1p: getting a “sugar-handle” on misfolded proteins
نویسندگان
چکیده
منابع مشابه
Htm1p: getting a “sugar-handle” on misfolded proteins
Mutations in the nuclear intermediate fi lament lamin A/C (LMNA) gene are associated with Emery-Dreifuss muscular dystrophy, but cause the disease by unknown mechanisms. Méjat et al. show that one mechanism involves the disruption of neuromuscular junctions. Muscle fi ber cells contain hundreds of nuclei. In normal fi bers, several nuclei cluster together under the cell membrane at sites of neu...
متن کاملGetting a handle on centrosomes
entrosomes are required for cytokinesis and are important in cell cycle progression—but how are centrosomes connected to these essential cellular functions at the molecular level? On page 535, Gromley et al. describe the maternal cen-triole protein centriolin, the first integral centrosome protein linked to both cytokinesis and cell cycle progression in vertebrate cells. Overexpression, siRNA s...
متن کاملER stress response: Getting the UPR hand on misfolded proteins
Unfolded proteins are constantly delivered to the ER lumen, where they must be removed by folding or degradation. Recent studies show that the 'unfolded protein response' controls essentially all aspects of ER function, coordinating these two fates for misfolded proteins in a process necessary for normal cell life.
متن کاملGetting a handle on exhibition catalogues
This paper describes work being carried out by CIMI (the Consortium for Interchange of Museum Information) on the analysis of exhibition catalogues. This is being undertaken as part of Project CHIO (Cultural Heritage Information Online). The project plans to use the SGML (Standard Generalized Markup Language) standard to express the structure and content of source materials, including exhibitio...
متن کاملLimb Movement: Getting a Handle on Grasp
The mechanical complexity of the hand is indisputable, but there is increasing evidence that its control is simplified in many tasks around synergic groups of muscles that effectively decrease the number of controlled degrees of freedom.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2009
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1841iti3